The INPS-MD prediction server
The INPS-MD (Impact of Non-synonymous mutations on Protein Stability - Multi Dimension) is a web server devised to prediction of protein stability change upon single point mutation. At the moment, two versions of the predictor are available either using protein sequence or 3D structure as starting point for the prediction task:
INPS predictor from sequence: Prediction of the impact of non-synonymous Single Nucleotide Polymorphisms (nsSNPs) on protein stability starting from protein sequence.
INPS predictor from protein 3D structure: Prediction of the impact of non-synonymous Single Nucleotide Polymorphisms (nsSNPs) on protein stability starting from protein structure.
For details see:
- Savojardo C., Fariselli P., Martelli P.L., Casadio R. "INPS-MD: a web server to predict stability of protein variants from sequence and structure", Bioinformatics (2016).
- Fariselli P., Martelli P.L., Savojardo C., Casadio R. "INPS: predicting the impact of non-synonymous variations on protein stability from sequence", Bioinformatics (2015) 31 (17): 2816-2821