INPS-MD (Impact of Non-synonymous mutations on Protein Stability - Multi Dimension) is a web server for predicting protein stability change (ΔΔG) upon single point variation. INPS-MD support either protein sequence (INPS-Sequence) or 3D structure (INPS-3D) as input for the prediction task.

INPS-MD is part of the ELIXIR infrastructure.

For details on the underlying method please see the Methods page.
For a tutorial on how to use the web server please see the Help page.

For more details and citations, please see INPS-MD papers:

• Castrense Savojardo, Piero Fariselli, Pier Luigi Martelli, Rita Casadio (2016) INPS-MD: a web server to predict stability of protein variants from sequence and structure, Bioinformatics, 32(16),2542–2544.
  Bioinformatics PubMed
• Piero Fariselli, Pier Luigi Martelli, Castrense Savojardo, Rita Casadio (2015) INPS: predicting the impact of non-synonymous variations on protein stability from sequence, Bioinformatics, 31(17), 2816–2821.
  Bioinformatics PubMed