Protein ID:
2OCJ:A
Submission date:
Nov. 12, 2024, 4:13 p.m.
Number of processed variants:
42
Completion date:
Nov. 12, 2024, 4:14 p.m.
| Wild-type residue |
Position |
Variant residue |
ΔΔG |
Effect |
| Q |
104 |
H |
-0.11
|
Neutral
|
| Q |
104 |
P |
0.37
|
Neutral
|
| T |
123 |
A |
-0.75
|
Weakly destabilizing
|
| A |
129 |
D |
-0.05
|
Neutral
|
| A |
129 |
E |
0.14
|
Neutral
|
| A |
129 |
S |
-0.07
|
Neutral
|
| M |
133 |
L |
0.57
|
Weakly stabilizing
|
| F |
134
|
L |
-2.83
|
Destabilizing
|
| V |
143
|
A |
-2.25
|
Destabilizing
|
| L |
145
|
Q |
-2.24
|
Destabilizing
|
| D |
148 |
E |
0.05
|
Neutral
|
| D |
148 |
S |
-0.02
|
Neutral
|
| T |
150 |
P |
0.14
|
Neutral
|
| P |
151
|
S |
-1.33
|
Destabilizing
|
| V |
157
|
F |
-1.71
|
Destabilizing
|
| Q |
165 |
K |
-0.14
|
Neutral
|
| Q |
167 |
E |
0.09
|
Neutral
|
| H |
168 |
R |
-0.74
|
Weakly destabilizing
|
| R |
174 |
K |
-0.48
|
Neutral
|
| R |
175
|
A |
-1.18
|
Destabilizing
|
| R |
175
|
H |
-1.13
|
Destabilizing
|
| C |
182 |
S |
-0.65
|
Weakly destabilizing
|
| I |
195
|
T |
-2.69
|
Destabilizing
|
| L |
201 |
P |
-0.49
|
Neutral
|
| V |
203 |
A |
-0.36
|
Neutral
|
| L |
206
|
S |
-1.4
|
Destabilizing
|
| Y |
220
|
C |
-2.19
|
Destabilizing
|
| D |
228 |
E |
0.12
|
Neutral
|
| I |
232
|
T |
-2.42
|
Destabilizing
|
| Y |
236 |
F |
0.27
|
Neutral
|
| M |
237
|
I |
-1.68
|
Destabilizing
|
| N |
239 |
Y |
0.5
|
Neutral
|
| C |
242
|
S |
-2.6
|
Destabilizing
|
| G |
245
|
S |
-1.14
|
Destabilizing
|
| R |
248 |
Q |
-0.76
|
Weakly destabilizing
|
| R |
249
|
S |
-1.72
|
Destabilizing
|
| I |
255 |
F |
0.39
|
Neutral
|
| S |
260 |
P |
-0.21
|
Neutral
|
| N |
268 |
D |
-0.74
|
Weakly destabilizing
|
| F |
270
|
C |
-2.33
|
Destabilizing
|
| R |
273 |
H |
-1.0
|
Weakly destabilizing
|
| R |
282 |
W |
-0.65
|
Weakly destabilizing
|
Weakly destabilizing
(-1 ≤ ΔΔG < -0.5)
Neutral
(-0.5 ≤ ΔΔG ≤ 0.5)
Weakly stabilizing
(0.5 < ΔΔG ≤ 1)