Prediction from sequence

Prediction of the impact of non-synonymous Single Nucleotide Polymorphisms (nsSNPs) on protein stability starting from protein sequence. Please, use the form below to submit a valid protein sequence in FASTA format along with the list of variations for which you want to predict the ΔΔG.

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Try out our new prediction method DDGemb based on Protein Language Models!

INPS-SEQ is described in the following article:

Piero Fariselli, Pier Luigi Martelli, Castrense Savojardo, Rita Casadio (2015) INPS: predicting the impact of non-synonymous variations on protein stability from sequence, Bioinformatics, 31(17), 2816–2821.

Bioinformatics PubMed

Paste your sequence
Paste variation list

Only one sequence, in FASTA format

Variation format: {WT}{POS}{VAR}, e.g. H20C. Please, provide at most 100 variations.