INPS - Bologna Biocomputing Group

The INPS-MD prediction server

The INPS-MD (Impact of Non-synonymous mutations on Protein Stability - Multi Dimension) is a web server devised to prediction of protein stability change upon single point mutation. At the moment, two versions of the predictor are available either using protein sequence or 3D structure as starting point for the prediction task:

WARNING: a new version of the INPSMD server web site is under development. We plan to release the new version on Junuary 1st 2025. From that date, the new version will be up and running and will replace this one. All the JOBs submitted to the current version will be lost when the new website will be released. Please, save your job results before Junuary 1st 2025. All JOBs still queued and/or running on December 31st will be stopped.

INPS predictor from sequence: Prediction of the impact of non-synonymous Single Nucleotide Polymorphisms (nsSNPs) on protein stability starting from protein sequence.

INPS predictor from protein 3D structure: Prediction of the impact of non-synonymous Single Nucleotide Polymorphisms (nsSNPs) on protein stability starting from protein structure.

For details see:

Savojardo C., Fariselli P., Martelli P.L., Casadio R. "INPS-MD: a web server to predict stability of protein variants from sequence and structure", Bioinformatics (2016).
Fariselli P., Martelli P.L., Savojardo C., Casadio R. "INPS: predicting the impact of non-synonymous variations on protein stability from sequence", Bioinformatics (2015) 31 (17): 2816-2821