INPS-3D (Impact of Non-synonymous mutations on Protein Stability) is a web server for predicting the impact of non-synonymous Single Nucleotide Polymorphisms (nsSNPs) on protein stability starting from protein structure.

To start using INPS-3D you need to submit PDB and mutation files using the upload fields below, insert the protein chain and press the "Submit job" button. The server accepts a single PDB file. Download example input data.

WARNING: a new version of the INPSMD server web site is under development. We plan to release the new version on Junuary 1st 2025. From that date, the new version will be up and running and will replace this one. All the JOBs submitted to the current version will be lost when the new website will be released. Please, save your job results before Junuary 1st 2025. All JOBs still queued and/or running on December 31st will be stopped.